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Patients should be asked if they are taking cyclosporinebeta carotene or vitamin E supplementslevothyroxinewarfarinantiepileptic drugsamiodaroneor antiretroviral drugs due to potential interactionssee DRUG INTERACTIONS

In 17 normal-weight subjects receiving XENICAL 120 mg three times a day for 6 daysXENICAL did not alter the bioavailability of nifedipineextended-release tablets

Some side effects can be seriousIf you experience any of these symptomscall your doctor immediately:

Patients should be advised to adhere to dietary guidelinessee DOSAGE AND ADMINISTRATIONGastrointestinal eventssee ADVERSE REACTIONSmay increase when XENICAL is taken with a diet high in fat30total daily calories from fatThe daily intake of fat should be distributed over three main mealsIf XENICAL is taken with any one meal very high in fatthe possibility of gastrointestinal effects increases.

Carcinogenicity studies in rats and mice did not show a carcinogenic potential for orlistat at doses up to 1000 mg/kg/day and 1500 mg/kg/dayrespectivelyFor mice and ratsthese doses are 38 and 46 times the daily human dose calculated on an area under concentration vs time curve basis of total drug-related material.

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