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Tell your doctor about all your current medicines and any you start or stop usingespecially:
These are not all the possible side effects of VIAGRAFor more informationask your healthcare provider or pharmacist.
Studies in vitro have shown that sildenafil is selective for PDE5Its effect is more potent on PDE5 than on other known phosphodiesterases10-fold for PDE680-fold for PDE1700-fold for PDE2PDE3PDE4PDE7PDE8PDE9PDE10and PDE11Sildenafil is approximately 4,000-fold more selective for PDE5 compared to PDE3PDE3 is involved in control of cardiac contractilitySildenafil is only about 10-fold as potent for PDE5 compared to PDE6an enzyme found in the retina which is involved in the phototransduction pathway of the retinaThis lower selectivity is thought to be the basis for abnormalities related to color visionsee Pharmacodynamics
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